Infectious canine hepatitis is a worldwide, contagious disease of dogs with signs that vary from a slight fever and congestion of the mucous membranes to severe depression, severe reduction in white blood cells, and deficiency of blood clotting. In recent years, the disease has become uncommon in areas where routine vaccination is used.

Infectious canine hepatitis is caused by a virus, canine adenovirus 1. Consumption of urine, feces, or saliva from infected dogs is the most common route of infection. Recovered dogs shed virus in their urine for at least 6 months. The virus targets the lining of blood vessels, the liver, kidneys, spleen, and lungs, though other organs are occasionally involved. Longterm kidney damage and clouding of the cornea of the eye (“blue eye”) result from immune-complex reactions after recovery from the disease.

Signs vary from a slight fever to death. The mortality rate is highest in very young dogs. The first sign is a fever higher than 104°F (40°C), which lasts 1 to 6 days and usually occurs in 2 stages. If the fever is of short duration, a low white blood cell count may be the only other sign. If the fever lasts for more than 1 day, other signs of illness, such as an increased heart rate, develop. On the day after the initial temperature rise, the white blood cell count drops and stays low throughout the feverish period. Clotting abnormalities can result in spontaneous bleeding that can be hard to control. The severity of the clotting problem seems to relate to the severity of the infection. Other signs of infection include apathy, loss of appetite, thirst, inflammation of the eyes, and a watery discharge from the eyes and nose.

Occasionally there may be abdominal pain and vomiting. The nose and mouth may be reddened or covered with small bruises. Enlarged tonsils and swelling of the head, neck, and trunk may occur.

Respiratory signs are not usually seen in dogs with infectious canine hepatitis. Although central nervous system involvement is unusual, severely infected dogs may develop convulsions (seizures) from brain damage. Slight paralysis, caused by bleeding in the brain, may also occur. After recovery, dogs eat well but regain weight slowly.

The resource for this information is

Learn more about NeoVac®DA2 for the treatment of Adenovirus.

Learn More